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Need clarification on term

Discussion in 'HEP C HIV' started by Jack Butler, Mar 18, 2009.

  1. Jack Butler

    Jack Butler Well-Known Member

    Hi. Can someone tell me what "genotype" refers to? I read the faq, but I'm still confused. Does genotype refer to the hepatitis virus? Or is it a characteristic of the sufferer's physical makeup? My gastro doc told me I have the best possible genotype for a good outcome with chemo, but never went into detail. What could he have meant? Thanks.

    jb

    "For small creatures such as we, the vastness is bearable only through love.”

    -- Carl Sagan - 1934-1996
     
  2. Jonesinhard

    Jonesinhard Well-Known Member

  3. Jack Butler

    Jack Butler Well-Known Member

    Thanks! That cleared it up.


    jb

    "For small creatures such as we, the vastness is bearable only through love.”

    -- Carl Sagan - 1934-1996
     
  4. kunzite52

    kunzite52 Well-Known Member

    GEEZ! I just typed an entire thing on Hepatitis C and lost it cause I forgot to sign in!

    Genotype refers to the type of Hepatitis C that you have, there are about 9 different types, only 1-3 are found here in the states. If the doc said you have the easiest to treat, then you have genotype 2a or 2b, which is a course of interferon and ribavirin tabs for 6 months time. The treatment is rigorous and you need to be prepared before you start it. I can help you with this as I work with Hepatitis Councils around the world.

    Also, you might need a liver biopsy to find out if you have fibrosis or cirrhosis of the liver. I have the cirrhosis; I did treatment in January 2006. I lasted only 19 days on treatment and was crippled with Rheumatoid Arthritis, had psoriasis, got very depressed, could not eat, my eyes were affected and on and on. I barely got out of bed for the 19 days I lasted on treatment and then they immediately took me off. Surprisingly, I had what was called a profound immune response and cleared the virus in 19 days. Thank God as I already have cirrhosis and the HepC was only advancing that.

    It is good to find out if you can get vaccinated for HepA and HepB as you can get co-infected and that is dangerous.

    Not all people react so severely to the treatment, some seem to fly through it. It does affect the mind, it is the strangest depression I ever encountered.

    You need to follow up on this and watch you diet, everything you eat is either processed through the kidneys or the liver. No high fats or lots of protein. You can increase antioxidants, those good little buggers who fight off the virus buggers by taking dry Vitamin E caps and Vitamin C and lots of broccoli etc.

    I hope I helped. IF you do decide to do treatment please email me, I belong to several sites and councils for hepC and would be able to help guide you through this.
    All the best,
    annie

    Anne
     
  5. mtgoat911

    mtgoat911 Well-Known Member

    this is god news, your type or genotype of hep c will respond well to tx!!!
     
  6. spring

    spring Administrator

    kunzite
    "Dry" vitamin E caps? What is is and why is it E in dry form? And what makes it better?

    I also have genotype 2b. I was diagnosed in 1992 but I figure I was infected sometime in the late 70s, early 80s. So far, my enzyme levels and viral load stay very low and up until a couple weeks ago, the only symptom I had was fatigue. The gastro doc kept refusing to treat me with interferon or even biopsy me because my viral count is so low. I didnt argue about it because I dont really want to have to go thru that anyway.

    I am now starting to feel a vauge ache in my right side and dont know if it's my liver or not tho nothing is swollen. I need to have some routine tests done but since I am recently insurance-less, it will have to wait.

    I attribute my ability to fight off the virus to my ongoing faithful intake of supplements including Milk Thistle, garlic tabs, vitamin E, high doses of VitaminC, alpha-lipoic acid, also SamE and colloidal silver(when I can afford them) to name a few.

    I was looking around online and found an article where they talk about Fluvastatin, an old statin cholestrol drug that looks very promising. They say it kills the virus. I need to read more about it tho. http://www.eurekalert.org/pub_releases/2008-05/uoo-ntf051408.php

    By the way kunzite, if it ever happens again that you lose your post due to not signing in first, keep backspaceing and you can usually find it. Happens to me often.

    <center>~Do the right thing and risk the consequences~</center>
     
  7. mtgoat911

    mtgoat911 Well-Known Member

    hey spring, i have a friend who is 25 years old in great shape, he got clean when he was 19, well, this friend works for a gi doctor who beleives that patients should take the tx while their viral load is low, and they are in good heatlh, the doctor believes that younger patients handle tx better, so my friend did the tx last year and the virus is gone
    maybe you could talk to another doc., its frustrating that some docs tell you to take the tx while your vl is low and others say wait until you get sick
     
  8. Jack Butler

    Jack Butler Well-Known Member

    Thanks, guys! I appreciate the encouraging words and the helpful information. I'm still in the learning stage when it comes to hep treatments.

    Bummer!
    Thanks! Maybe you can clarify something for me. I contracted hep B, while overseas, over 35 years ago. After making it through the initial active period, the years that followed passed in varying degrees of intoxication, but I was obsessive about never sharing and never using unsealed paraphrenalia. Then about 1986 my internist told me I had hep A, two strains of hep B, and hep C. I think I had an out-of body experience right there on the spot. In '03 I started taking methadone. On 1/18/07 I went cold turkey and now I'm 2-plus years drug-free. In the past few months I've had a lot of medical testing and procedures done. My GP and my gastro doc both tell me I have hep C, but not A or B. How is this possible? Does B mutate into C over time?
    Wow! Sounds like you had a rough way to go. I'm sorry to hear that. So what is the status on the cirrhosis? Are you on a donor list? Have things improved since clearing the virus? If so, how? I'm really curious to know how recovery from hep progresses after treatment.

    I haven't had a liver biopsy done. But my gastro doc ran several tests and had an ultrasound done. The ultrasound showed my liver folds over on itself, which is apparently not abnormal, just not real common. Hepatitis aside, my liver appears to be i
     
  9. spring

    spring Administrator

    Mt Goat,
    The reason why my Doc wont treat me is because my body has been fighting it off by itself. My viral count stays well below 50,000 and according to him most who are treated have counts in the millions. Some people's bodies can actually eradicate it totally without interferon treatment. He says the treatment could cause me more harm than good at this point since it destroys good cells as well as the bad. I s'pose I could request the tx but would rather not at this point.

    Jack, you said;
    Thanks! Maybe you can clarify something for me. I contracted hep B, while overseas, over 35 years ago. After making it through the initial active period, the years that followed passed in varying degrees of intoxication, but I was obsessive about never sharing and never using unsealed paraphrenalia. Then about 1986 my internist told me I had hep A, two strains of hep B, and hep C. I think I had an out-of body experience right there on the spot. In '03 I started taking methadone. On 1/18/07 I went cold turkey and now I'm 2-plus years drug-free. In the past few months I've had a lot of medical testing and procedures done. My GP and my gastro doc both tell me I have hep C, but not A or B. How is this possible? Does B mutate into C over time?

    I also contracted A and B in my earlier days. I got A from the drinking water at a 70s music festival. Then I got B in the late 70s after using a Hep B "carrier's" syringe. My body got rid of both by itself. According to tests, I am not a carrier of B tho I show the antibodies that I once had it.
    I'm no medical expert but I'm pretty sure that B doesnt morph into C. They are two totally different types.

    Do you know what your viral load/count is Jack?

    About the fatigue, I just cant say enough about SamE. It GREATLY helps with the fatigue, plus depression and is also an anti-viral as a side benefit. I truly think that SamE along with my daily Vitamin C and Milk Thistle has helped me along all these years.
    Just a little advice I learned along the way about SamE tho...you gotta take B complex with it (vitamin B6, B12, and Folic Acid mainly) because it helps the absorption rate and balances out the homocystene levels....it's a necessity to take B complex.

    I'm not suggesting that you dont take the chemo treatment. But even so, it cant hurt to self treat with some (safe) supplements.

    For me personally, it's a choice to use natural means to treat it.



    <center>~Do the right thing and risk the consequences~</center>
     
  10. Jack Butler

    Jack Butler Well-Known Member

    Thanks for sharing your experience on that. I suppose I could have processed B out of my system, if that's possible. Same for the A. (though I don't recall ever being sick with A) Not sure about the diagnosis of the 2nd strain of B. I'm not ruling out lab or doctor mistakes here. The real question mark for me is how did I pick up C? I stopped being promiscuous and using IV drugs at the onset of the big AIDS scare in the '80's. Haven't violated either of those rules since. So how did I pick up C? I guess I may never know.
    No I don't. That should be available to me through my gastro doc though. So I'll see if I can find out.
    Thanks, Spring. I'll definitely look into the SamE.
    It may be a perfect fit as I'm waiting to get hooked back into the chemo route. The anti-depressive aspect is a nice extra.

    So much to take in. So much yet to learn. Need to remind myself to breath. Ha! ha! Thanks.

    jb

    "For small creatures such as we, the vastness is bearable only through love.”

    -- Carl Sagan - 1934-1996
     
  11. spring

    spring Administrator

    I am guessing I got mine the same way I got the Hep B, by sharing a syringe. Like you, that's something I also stopped doing in the early 80s during the initial AIDs scare...but not soon enough is my guess.
    The reason I wasnt diagnosed with Hep C along with the Hep B or during later tests was because it wasnt included in the routine Hep screens and required a special test. So I may have had it then but just didnt know it.

    I was diagnosed with it in 1992 because I requested that special test after learning that one of my friends got her diagnosis of being positve for it. Up until then I dont think they even had a name for it. It was called nonA/nonB (or something like that) if I remember correctly.

    There have been people who dont have high risk factors being diagnosed with Hep C. They happen to find out by accident while getting blood tests for insurance or jobs. It has become an epidemic and no one seems to know why.

    I can undrstand why it's flourishing better than the AIDs virus tho. The AIDs virus can only live for a minute or two when exposed to the air while the Hep C virus can live for days. Bleach kills the Aids virus and doesnt kill the Hep C virus so it's a tough one.

    <center>~Do the right thing and risk the consequences~</center>
     
  12. mtgoat911

    mtgoat911 Well-Known Member

    jack 35yrs ago many medical professionals did not know about hep c, maybe you have always had hep c and back then you were just imporperly diagnosed
     
  13. spring

    spring Administrator

    Hi Anne, Do you happen to know how long you had Hep C? Are/were you in good health otherwise? I think this is simply amazing that you were able to get rid of it with only 19 days of tx. And the fact that you have cirrhosis makes it even more amazing! You are certainly a blessed one!

    Also, I asked you a question elsewhere in this same thread about "dry" Vitamin E. Maybe you havent read it yet. Could you explain the difference to me please?

    <center>~Do the right thing and risk the consequences~</center>
     
  14. kunzite52

    kunzite52 Well-Known Member

    Spring I had hepC for at least 35 years and that is why I got cirrhosis. I was not even a heavy drinker.

    Yes before HepC was discovered in 1989 (and unfortunately thereafter) it was often misdiagnosed as HepB. IF YOU HAVE HEPC you need to get inoculated for both HepA and HepB. One can get co-infected.

    If you lie down and push up under the right side of your rib cage, that is where your liver is. It does not usually hurt unless your viral load is really high. HOWEVER, there are times when mine hurts. While I have cirrhosis and that does affect my health and my spleen, which is up under the left rib cage, it is not nearly as bad as when I had hepC.

    The chronic fatigue is one side effect of hepC. I had it so bad. I worked as a teacher then and could not figure out why I kept falling asleep at the wheel driving home. It happened all the time, to the point where I did not even drive home during the week and stayed instead with my cousin who was about 15 minutes from the school.

    Spring, HepC is an epidemic and there is a reason why. Although the virus was discovered in 1989 the red cross was not testing their blood for it until about 1998. I know this cause my son gives blood (not the addict the other one) and he did so for years and they did not test him for hepC until about 1998. So all those transfusions, hepC happened. Also most vets are infected. Especially those from Vietnam and Desert Storm. The ONLY thing that kills the virus in blood is bleach. There were cases of the army using syringes after sterilization on other people. The normal sterilization process will not kill the virus.

    Ah yes dry Vitamin E. A bad liver cannot process the oil based supplements. Vitamins like A and E are digested and processed through the liver not the kidneys, like vitamin C is, which is water soluble. Knowing this I made the decision to opt for dry E which is sold at health food stores. Also dry E in combo with vitamin C helps the immune system. Hepatitis C wreaks havoc on the immune system. Low WBC are the most common reason.

    Spring the hepatitis affected my spleen and digestion. It also affected the serotonin in my brain and made sleeping a near impossibility for years for me. I would simply pass out and then wake up wide awake after 4 hours sleep. I was exhausted all the time. I rarely take anything to sleep anymore. I walk and now garden. I move every day as much as possible in order to make my body tired.

    The treatment resulted in Rheumatoid Arthritis for me, which is also related to the immune system. I have it in my legs, my feet, my back and it is very hard to walk, not that that stops me. I walk through the pain, that is what I do.

    Jack if you can determine how you got the C let me know. I have come up with many ways I could have gotten it. Bad dental procedures done in the 70s, 80s and 90s are one way to get it and I had my wisdom teeth extracted and a serious infection followed. It is very hard to get it from sex or to have it travel over the placenta and infect a baby. You can get it from a bite. From a person obviously. The most common ways are blood transfusions (of bad blood) and IVDuse. I know people who have more than one strain of it.

    It is really important that I get my blood tested every six months. When I had it my platelets were off the charts and I was a bleeder. Took me forever to stop bleeding. If you have a bad liver you will see spots on the palms of your hands, near your wrist. I have those, also your feet get red as well. If you ever turn yellow something is very wrong and you need to deal with it immediately.

    Also every year I have to have an endoscopy as when part of the liver is cirrhotic the blood will seek other avenues to your body. In your esophagus these little veins form called varices and t
     

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